A BENCH-TO-BEDSIDE APPROACH
The Manchester Cancer Research Centre brings together world-class research into cancer biology, novel therapeutics and clinical trials. Our work aims to translate new insights from the laboratory into better, more effective treatments for cancer patients by integrating basic, translational and clinical research efforts across a variety of priority research themes.
Groups across the Centre carry out laboratory-based discovery research, in order to gain a better understanding of how tumours start, grow, spread and return in different tissues. They aim to identify key cancer-causing genetic mutations and to explore the similarities and differences between various cancers, and between normal and tumour tissue. We also have groups carrying out comprehensive studies into cell biology - including cell adhesion, the cell cycle, cell division, cell regulation and cell signalling - as well as into stem cells and the extracellular matrix.
Our researchers work to develop new anti-cancer treatments, using both small-molecule and immunotherapy drugs, as well as surgical, chemotherapy and radiation-based approaches. Importantly, we are learning how to choose the right therapy option by predicting the potential benefit and outcome for each individual cancer patient.
Bringing the latest therapies and interventions to the clinic requires a detailed understanding of their safety and efficacy. Our large clinical trials team leads multicentre studies into novel agents that are vital to the introduction of more effective cancer treatments. Information and patient samples from the clinic can be sent back into the laboratory to allow our basic researchers to follow the right path.