The preliminary conference programme is as follows, subject to change. Download at-a-glance version here.
Sunday 14 July 2019
11:30 - 13:30 Delegate Registration
13:30 - 15:00 Session 1: Welcome and Keynote Talk
13:30 - 14:00 Welcome and Opening Remarks
Professor Rob Bristow & Dr Natalie Cook
14:00 - 15:00 Opening Keynote Lecture
Professor Lillian Siu (Princess Margaret Hospital, Canada)
"Phase I: past and present"
15:00 - 15:30 Coffee break
15:30 - 17:00 Session 2: Debate Session
Chair: Professor Rob Bristow
The Big Debate: “This house believes every cancer patient should have comprehensive genomic profiling prior to each experimental therapy”
Debate leads: Professor Jeff Evans (Beatson Institute, UK) and Dr Tim Yap (MD Anderson, USA)
Monday 15 July 2019
09:00 - 10:30 Session 3: Novel targets and their impact on trial designs
Chairs: Professor Duncan Jodrell and Dr Louise Carter
Professor Caroline Springer (Cancer Research UK Manchester Institute, UK)
"CRUK Manchester Institute Drug Discovery Unit: Emerging Targets in Drug Development"
Professor Ruth Plummer (University of Newcastle, UK)
"Rare targets and their impact on the evolution of trial design"
Professor Sarah Blagden (University of Oxford, UK)
"Challenges of delivering platform based trials"
Professor Pamela Munster (UCSF, USA)
"Novel targets in epigenetics"
10:30 - 11:00 Coffee break
11:00 - 12:30 Session 4: Precision Medicine
Chairs: Dr Matt Krebs, Professor Richard Marais
Professor Caroline Dive (Cancer Research UK Manchester Institute, UK)
"Liquid Biopsy for Precision Medicine’"
Professor Gary Middleton (University of Birmingham, UK)
"The promise and pitfalls of platform trials"
Professor Steven Jones (Michael Smith Genome Sciences Centre, BC Cancer, Canada)
"Using genomics and transcriptomics to develop precision medicine in oncology in British Columbia.”
12:30 - 13:30 Lunch
13:30 - 14:30 Session 5: Keynote
Professor Skip Burris (Sarah Cannon Research Institute, USA)
“Next steps for phase I”
14:30 - 15:00 Coffee break
15:00 - 16:30 Session 6: Immuno-oncology
Chairs: Dr Anne Armstrong, Dr Elaine Kilgour, Professor Tracy Hussell
15:00 - 15:30 Dr Santiago Zelenay (CRUK Manchester Institute, UK)
"Manipulating inflammation to raise cancer immunogenicity"
15:30 - 16:00 Dr Stefan Symeonides (University of Edinburgh, UK)
"Combination studies - immunotherapies and other targeted agents”
16:00 - 16:30 Dr Charles Ferté (MedImmune)
19:00 - Conference Dinner, Science and Industry Museum (SIM)
Tuesday 16 July 2019
09:00 - 12:30 PARALLEL NURSING WORKSHOP - more information here
09:00 - 10:30 Session 7: Radiotherapy combinations
Chairs: Professor Tim Illidge, Professor Kaye Williams
09:00 - 09:30 Professor Kaye Williams (The University of Manchester, UK)
"RADCOM- a consortium approach to accelerate novel drug RT combinations to clinical trials"
09:30 - 10:00 Professor Anthony Chalmers (University of Glasgow, UK)
"Combining radiotherapy with inhibitors of the DNA damage response: are conventional phase I trials giving us the data we need?"
10:00 - 10:30 Professor Dave Raben (University of Colorado, USA)
"The Windows of Opportunity - Radiation and Drug Development Phase I Trials in 2019"
10:30 - 11:00 Coffee break
11:00 - 12:30 Session 8: Advanced Therapies
Chairs: Dr Fiona Thistlethwaite, Professor Robert Hawkins
11:00 - 11:30 Professor Brian Bigger (The University of Manchester, UK)
"Developing stem cell gene therapies for childhood dementias"
11:30 - 12:00 Dr Sophie Papa (King's College London, UK)
"CAR T cells and solid tumours: efficacy, toxicity and practicality"
12:00 - 12:30 Dr Reno Debets (Erasmus Medical Centre, Netherlands)
"T cells engineered with MAGE-C2 TCR to treat patients with melanoma and head-and-neck cancer: a 2019 trial in Rotterdam"
12:30 - 13:30 Lunch and poster session
13:30 - 15:00 Session 9: Trial Design Methodology
Chairs: Professor Andrew Hughes, Professor Caroline Dive
13:30 - 14:00 Question 1
Do “rules based” designs offer better value (in time, cost and identifying the recommended phase II dose range(s) than model-based designs?
Percy Ivy (National Cancer Institute, USA): This conference believes that "rules based" designs offer better value
Adrian Mander (University of Cambridge, UK): This conference believes that "model based" designs offer better value
14:00 - 14:30 Question 2
How can we bring phase I into the digital age?
Donal Landers (Cancer Research UK Manchester Institute): Can the patients ever become co-scientists with us in the trial?
Steffan Stringer (Foundry Health, UK): Can Investigator sites ever become digital hubs?
14:30 - 15:00 Question 3
What is the primary purpose of phase I?
Udai Banerji (ICR, London, UK): The primary purpose is to define a recommended dose range for phase 2
Glen Clack (University of Sheffield, UK): The primary purpose is to achieve drug registration through modular trial designs
Session 10: Closing Remarks Professor Andrew Hughes